Popular Science: Wearable PET Scanner For Rats Enables Real-Time Monitoring of Awake, Moving Animals’ Brains

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A new type of brain scanner attaches to a rat’s head, allowing neuroscientists to study the brains of fully awake, mobile lab animals for the first time.

The RatCAP, for Rat Conscious Animal PET, is worn over a rat’s head like a crown. A system of springs and motion stabilizers help the rat hold its head high and walk around.

Positron emission tomography scans enable scientists to study the molecular processes of brain activity, both in animals and in humans. To use the scanners, a patient has to lie down with his or her head in a machine. But good luck telling a lab rat to sit still.

Usually, animals are immobilized or given anesthesia, although those methods make it impossible to study the correlation between neurochemistry and the animals’ behavior, according to David Schlyer, a physicist at Brookhaven National Laboratory. Scientists wanted a scanner that could correlate PET data with behavioral data.

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