Archives

RatCAP: a small, head-mounted PET tomograph for imaging the brain of an awake rat

September 20, 2019|RatCAP | 1 Min Read

This paper will describe the novel features and challenges of this new detector, along with preliminary results obtained with a pair of block detectors used in a configuration similar to […]

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Initial studies using the RatCAP conscious animal PET tomograph

September 20, 2019|RatCAP | 1 Min Read

Construction of the first working prototype detector has been completed and its performance characteristics have been measured. First preliminary images have been obtained using 18F-FDG and 11C-methamphetamine, which show comparable […]

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System Performance Simulations of the RatCAP Awake Rat Brain Scanner

September 20, 2019|RatCAP | 1 Min Read

The effects of the RatCAPs small ring diameter ( 40 mm) and its block detector geometry on image quality for small animal studies have been investigated. In addition to Monte […]

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Integrating PET with behavioral neuroscience using RatCAP tomography

September 20, 2019|RatCAP | 1 Min Read

Small animals typically require anesthesia to remain still during PET imaging, which places a burden on behavioral studies. Our approach integrates PET with behavioral observations using a miniature PET scanner […]

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Front-End Electronics for the RatCAP Mobile Animal PET Scanner

September 20, 2019|RatCAP | 1 Min Read

We report on the development of the front-end electronics for RatCAP. So far, three ASIC prototypes implementing part of the electronics were sent to fabrication. Results from the characterization of […]

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The RatCAP Front-End ASIC

September 20, 2019|RatCAP | 1 Min Read

We report on the design and characterization of a new ASIC for the RatCAP. The ASIC is composed of 32 channels, each consisting of a charge sensitive preamplifier, a 5-bit […]

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Digital Coincidence Processing for the RatCAP Conscious Rat Brain PET Scanner

September 20, 2019|RatCAP | 1 Min Read

In order to maximize system performance, offline digital coincidence data processing algorithms including offset delay correction and prompt and delayed coincidence detection have been developed and validated. The experimental results […]

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Next Generation of Real Time Data Acquisition, Calibration and Control System for the RatCAP Scanner

September 20, 2019|RatCAP | 1 Min Read

In order to maximize system performance, offline digital coincidence data processing algorithms including offset delay correction and prompt and delayed coincidence detection have been developed and validated. The experimental results […]

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Simultaneous assessment of rodent behavior and neurochemistry using a miniature positron emission tomograph

September 20, 2019|RatCAP | 1 Min Read

The simultaneity of the PET and behavioral data provides a multidimensional tool for studying the functions of different brain regions and their molecular constituents. Key components include the ‘rat conscious […]

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Rapid [18F]FDG Uptake in Brain of Awake, Behaving Rat and Anesthetized Chicken has Implications for Behavioral PET Studies in Species with High Metabolisms

September 20, 2019|RatCAP | 1 Min Read

The rapid uptake times of 18F-FDG both in the awake, behaving rat and the anesthetized chicken together with the rapid dynamics of rat and chicken behavior suggest that uptake times […]

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